About the Journal
Brain-X
is a peer-reviewed, online open access journal that publishes the cutting-edge discoveries and technologies works providing novel insights into all aspects of brain, neuroscience and neurology. Interdisciplinary studies utilizing approaches of mathematics, physics, chemistry, engineering, materials, or information science to address the issues of brain, neuroscience and neurology are particularly encouraged.
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We cordially invite you to submit manuscripts to Brain-X . The Article Publication Charge is waived for accepted manuscripts from 2023-2025 .
Articles
TurboID coupled with APEX2: Application prospects for deciphering proteome trafficking and interactions in neuroscience
- 7 December 2023
Calcitonin gene‐related peptide and persistent corneal pain: A trigeminal nerve sensitization perspective
- 6 December 2023
Graphical Abstract

High calcitonin gene-related peptide (CGRP) levels cause central sensitization, which may be associated with the overactivation of glial cells and various pain receptors. CGRP induces MAPK14 activation and nitric oxide (NO) secretion on the surface of neurogliocytes, and the produced NO stimulates CGRP secretion through the N-type calcium channel. CGRP increases N -methyl-d-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors on the postsynaptic membrane.
Sonogenetics as a promising approach for non‐invasive ultrasound neuromodulation of deep neural circuits
- 3 December 2023
Anchoring neurostimulation on crossed cerebellar diaschisis for motor recovery in adults with hemiparesis
- 2 December 2023
Virtual external stimulation promotes the transformation of the brain state from early mild cognitive impairment to health
- 29 November 2023
Graphical Abstract

To evaluate how external stimulation of brain regions affects the brain state, our study used the exact controllability theory to determine potential targets and applied a whole-brain dynamic model via virtual stimulation to promote the transformation of the brain state from early mild cognitive impairment (EMCI) to health. The findings reveal the underlying brain mechanisms of cognitive decline in patients with EMCI, which could help in designing more effective therapeutic interventions.
Advancements and implications of semantic reconstruction of continuous language from non‐invasive brain recordings
- 17 October 2023
Latent embeddings: An essential representation of brain–environment interactions
- 17 October 2023
Understanding the brain with attention: A survey of transformers in brain sciences
- 12 October 2023
Graphical Abstract

This survey provides a comprehensive review of the development and application for Transformers in brain sciences. It covers eight widely concerned brain science scenarios to provide vital details and discussions for the latest Transformer researches. By exploring the current challenges and potential research directions, it would be expected to provide a convenient reference for researchers in related fields.
Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospects
- 12 October 2023
Graphical Abstract

This paper describes the role of inflammation in sensorineural hearing loss (SNHL). Inflammation affects SNHL primarily via cochlear immunity, microcirculation, vasospasm, and glutamate metabolism, often accompanied by immune cell infiltration, altered blood flow, ischemic damage, and synaptic injury. A comprehensive anti-inflammatory approach is undesirable, and studying inflammation-related mechanisms will aid the search for potential targets in SNHL.
Edge‐centric functional network reveals new spatiotemporal biomarkers of early mild cognitive impairment
- 12 October 2023
Graphical Abstract

In contrast to existing studies that focus on the correlations between brain regions, our study is based on the high-order edge network and innovated to explore the correlation between brain region pairs from the perspective of space and time, search for new biomarkers, and explore the pathogenesis of early mild cognitive impairment, which is conducive to delaying its development to Alzheimer's disease and promoting medical developments.
Reactive oxygen species targeted biomaterials for spinal cord injury therapy
- 10 October 2023
Graphical Abstract

This review provides an extensive overview of the recent advancements in reactive oxygen species (ROS)-targeted biomaterials tailored for spinal cord injury (SCI) treatment, emphasizing their ability to effectively clean excessive ROS, modulate inflammation, and reduce secondary injuries. The review also showcases their potential for future translational research involving SCI clinical therapies, which will enable the ongoing enhancement and optimization of these biomaterials to benefit individuals with SCIs.
Novel brain‐inspired optomemristive feedback neuron for neuromorphic computing
- 4 October 2023
Understanding the heterogeneous immune repertoire of brain metastases for designing next‐gen therapeutics
- 1 October 2023
Graphical Abstract

Advanced cancer patients often develop brain metastases, but their molecular and immunological features remain poorly understood due to challenges in biopsy. This perspective highlights recent advances in immune landscape profiling of brain metastases, with an emphasis on tumor-reactive T cells, and summarizes innovative technologies for tracking tumor dynamics and designing targeted therapies.
The mechanism of bone healing after traumatic brain injury
- 28 September 2023
Direct neuronal reprogramming for central nervous system regeneration
- 28 September 2023
ChatGPT: The cognitive effects on learning and memory
- 20 September 2023
Graphical Abstract

The integration of ChatGPT into the domains of learning and memory holds the potential to transform the entire field of education. This article explores the potential positive and negative effects of increased engagement with artificial intelligence, offering strategies for optimizing its benefits while mitigating its drawbacks, and highlights areas that can benefit from further research. In this way, it seeks to ensure that ChatGPT operates as an adjunctive educational tool that complements human cognitive processes without damaging them.
Prediction of the hand function part of the Fugl‐Meyer scale after stroke using an automatic quantitative assessment system
- 22 August 2023
Graphical Abstract

This study aims to quantitatively assess the motor function of the hand in stroke patients with a self-developed system named the Hand Automatic Quantitative Assessment System (HAQAS) using state-of-the-art machine learning algorithms. There were high correlations between features automatically collected by the HAQAS and Fugl-Meyer scales in all the sub-items. Our proposed automatic FMA system is easy and transparent to use in clinical settings and would greatly reduce the workload of physical therapists and clinicians.
Target localization intervention and prognosis evaluation for an individual with mild cognitive impairment
- 22 August 2023
Graphical Abstract

A single brain region state dynamics model was developed to simulate blood oxygen level-dependent signals of a patient with early mild cognitive impairment. Multiple complex network centralities were comprehensively considered to locate the intervention targets, and a multi-brain collaborative control scheme was designed and verified at the brain region and subnetwork levels.
Heart–brain team approach of acute myocardial infarction complicating acute stroke: Evidencing the knowledge gap
- 15 August 2023
Nanomedicines for Alzheimer's disease: Therapies based on pathological mechanisms
- 28 July 2023
Tribo-ferro-optoelectronic neuromorphic transistor of α -In2 Se3
- 18 July 2023
Graphical Abstract

This paper proposes a tribo-ferro-optoelectronic neuromorphic transistor with multimodal synaptic plasticity by combining a triboelectric nanogenerator and a two-dimensional ferroelectric α-In2 Se3 transistor. The device enables associative learning and Boolean logic through the synergy of mechanical displacement, ferroelectric polarization, and light illumination.
Potential roles of transformers in brain tumor diagnosis and treatment
-  13 July 2023
Graphical Abstract

Transformers play an essential role in the brain tumor segmentation of MRI images, the MRI- and histopathology-based grading of brain cancer, brain tumor molecular expression prediction, the classification of primary brain metastasis sites, voxel-level dose and brain tumor radiotherapy outcome prediction, synergistic prediction, and the pathway deconvolution of drug combinations. This review aimed to discuss the increasing applications of Transformers in real-time brain tumor detection and therapy, indicating their broad prospects and potential.
Functional magnetic resonance imaging study of children's brain development in phonological processing and speeded naming
-  10 July 2023
Revolutionary delivery system enables precise protein transportation
-  29 June 2023
SPEAC‐seq: A new method to investigate astrocyte‐microglia crosstalk
-  28 June 2023
A new mechanism of consciousness recovery from anesthesia regulated by K+ -Cl– cotransporter KCC2
-  1 June 2023
The oscillating mystery: The effects of forty-hertz entrainment in treating Alzheimer's disease
-  30 May 2023
Waking up neural stem cells through inhibition of mitochondrial pyruvate import
-  29 May 2023
Novel mechanism of DNA repair in neurons opens promising avenues for combatting neurodegenerative diseases and brain aging
-  19 May 2023
3D printing‐based full‐scale human brain for diverse applications
-  5 April 2023
Graphical Abstract

This paper aims to develop a set of three-dimensional (3D) printing approaches to fabricate customized full-scale human brain models for surgery training as well as specialized brain patches for wound healing after surgery. Brain patches with complex geometries can be directly printed in a stimuli-responsive yield-stress support bath, while full-scale human brain models are created by an inverse fabrication strategy.
3‐hydroxybutyrate in the brain: Biosynthesis, function, and disease therapy
-  27 March 2023
Nucleic acid delivery by ionizable nanocarriers for brain disease treatment
-  26 March 2023
Brain-X: A new interdisciplinary journal for advancing neuroscience research
- 21 March 2023
Systolic pressure target after endovascular thrombectomy in acute large-vessel occlusion ischemic stroke patients: Comment on ENCHANTED2/MT
- 21 March 2023
Rhythmic calcium ion activity related to glioma growth reveals the mechanism of ion transmission
-  21 March 2023
more
The following is a list of the most cited articles based on citations published in the last three years, according to CrossRef.
Nanomedicines for Alzheimer's disease: Therapies based on pathological mechanisms
- 28 July 2023
Recent issues
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Volume 1, Issue 4December 2023
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Volume 1, Issue 3September 2023
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Volume 1, Issue 21 June 2023
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Volume 1, Issue 1March 2023